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I like the Chargers at home this is when they turn it up and as you can see their defense is playing at an all time high this year being #1 in the league while their passing game is top flight too. They play the visiting 49ers who won big last week, but now Troy Smith has to contend with the best team on the West Coast in the Chargers. There is reason this spread is so big. I've been fooled into taking the dog here in the past and the team that's favored dominated anyway. I think this is another one of those games. Chargers only struggle on offense when a team has a pass rush and strong cover corners. I'm sorry Nate Clements is solid but he's not Revis or Asimghua. Look for the Chargers to really hold the 49ers offense intact which is why this game goes under I expect a 24-7 or 31-7 type game.